yam8+, and the GTPase rho3+enhances cfr1Δ and bch1Δ sensitivity

to stress. We have also analyzed the effect of eliminating

different stress-responsive signaling pathways in the sensitivity of

exomer mutants. We have found...

Preimplantation development of the mammalian

embryo consists of stages that include formation of the

zygote, blastocyst formation and implantation of the

embryo into the uterus. Depending on the animal, ...

effects. A defect in the death receptor signaling pathway is a feature of CRC. The ligand of these receptors belongs to the tumor necrosis factor family, and that are particularly expressed by cells of the immune system, and that induce apoptosis in a...

inherent chemotherapy resistance, 3) its well-stablished role in different cellular functions, 4) complicated interaction with

other signaling pathways and 5) a lack of effective targeted therapy. Cancer stem cells found within tumors have the ability...

It is entirely accepted that a metabolic change in purine nucleotide concentration occurs during carcinogenesis which facilitate the pathological process of malignant cells such as proliferation, invasion and metastasis. ...

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive types of cancer, requiring reliable biomarkers for prognosis and therapeutic responsiveness. TWIST1, as an important factor responsible for metastasis ...

Introduction: Signaling pathways are not isolated from their

surroundings. They are also intervened by other signaling pathways;

known as “crosstalk mechanism”. One of the most important

crosstalk mechanisms is the insulin...

Signaling pathways are not isolated from their surroundings. They are also intervened by other signaling

pathways known as “crosstalk mechanism”. One of the most important crosstalk mechanisms is the insulin-

EGF network. Although...