Tanacetum parthenium (T.p.) is used in folk medicine as a treatment wiedly. We

reported the analgesic effect of T.p. flowers and leaves previously. This study was

designed to find how this mechanism is occurred ...

the anti-nociceptive effect of the extract. Discussion: The involvement of sertoninergic system in anti-nociceptive effect of the T.p. extract is proposed by the results. Also the involvement of opioidergic system has to be mentioned in this effect....