The high incidence of esophageal squamous cell carcinoma (ESCC) has been reported in selected ethnic populations including North of Iran. Low survival rate of ESCC is partially due to the presence of stem-like cancer cells ...

Objective:High and growing statistics of cancer related death worldwide, which is due to the low efficiency of current therapeutic strategies, has made it crucial to search for novel approaches against resistant and ...

Cancer therapy is still very challenging since current modalities are not effective enough to

eradicate chemoradiotherapy resistance and metastatic cancer cells. Valproic acid (VPA) is a

short chain fatty ...

Valproic acid (VPA) is a histone deacetylase inhibitor that has been an object of interest to clinicians for its promising potency in cancer therapy, as it induces apoptosis and differentiation, and enhances of chemotherapy ...

In this study, the activity of 15-LOX-1 was first evaluated in two prostate cancer cell lines PC3 and DU145. Considering the enzyme inhibitory potency of 5farnesyloxycoumarin (5f), the cytotoxic effects of this compound was ...

BACKGROUND:

Prostate cancer is one of the leading causes of cancer related deaths in males worldwide. Overexpression of 15-lipoxygenase-1 (15-LOX-1) enzyme and high activity of its metabolic pathway is reported to ...

گونه های مختلف Ferula از خانواده ی Apiaceae به صورت خوراکی در طب سنتی ایران استفاده می شوند و بسیاری از آن ها قادر به سنتز ترکیبات کومارینی هستند که این ترکیبات فعالیت های بیولوژیکی متعددی از خود نشان داده اند. Umbelliprenin ...

سرطان پروستات دومین سرطان شایع در مردان جهان و تشکیل دهنده 19% کل سرطان ها در کشور های در حال توسعه است. بیان بالای آنزیم 15-لیپواکسیژناز-1(15-LOX-1) در تومورهای پروستات گزارش شده است. مشتقات کومارین با داشتن اثر مهاری بر ...

Lipoxygenases are lipid-peroxidizing enzymes that have many important roles in human diseases including cancer. Two different 15-lipoxygenase (15-LOX) enzymes, 15-LOX-1 and 15-LOX-2, are found in humans, with distinct ...