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RISAn in-situ forming implant formulation of naltrexone with minimum initial burst release using mixture of PLGA copolymers and ethyl heptanoate as an additive: In-vitro, ex-vivo, and in-vivo release evaluation
سال: 2018
خلاصه:
An in-situ forming implant formulation of naltrexone (NTX) was achieved based on a minimum initial burst release of NTX in the in-vitro release medium using a Box-Behnken design. Variables such as percent of copolymer by ...
Preparation and Investigation of Sustained Drug Delivery Systems Using an Injectable, Thermosensitive, In Situ Forming Hydrogel Composed of PLGA-PEG-PLGA
سال: 2012
خلاصه:
Abstract. In situ gelling systems are very attractive for pharmaceutical applications due to their biode-
gradability and simple manufacturing processes. The synthesis and characterization of thermosensitive
Sustained Delivery of Amphotericin B and Vancomycin Hydrochloride by an Injectable Thermogelling Tri-Block Copolymer
سال: 2013
خلاصه:
ABSTRACT: Because traditional drug delivery poses many disadvantages such as poor compliance of patients and a drug plasma level variation, novel drug delivery systems containing controlled release drug vehicles become ...