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RISThe molecular mechanism of protein denaturation in supercritical CO2: The role of exposed lysine residues is explored
Although there are many interests to use proteins in supercritical CO2, protein destabilization in this solvent is the major drawback. This is because of the non-natural CO2 environment which imposes essential instability ...
The open lid conformation of the lipase is explored in the compressed gas: New insights from molecular dynamic simulation
The advantages of enzymatic reactions in compressed gases such as supercritical CO2 is
limited due to the enzyme inactivation. But recent experimental observations reported the
high activity of enzymes such ...
How enzymes can remain active and stable in a compressed gas? New insights into the conformational stability of Candida antarctica Lipase B in near-critical propane
Although it has been known that many of the enzymes may be instable in harsh conditions of
supercritical CO2, recent experimental studies argued that the enzymes are active and stable
in near-critical propane ...
Effect of solvent surface tension on the radius of hematite nanoparticles
In this work, the hematite (Fe2O3) nanoparticles were synthesized by homogeneous precipitation in alcohol (tert-butanol) /water mixed solvents with the various surface tensions. The surface tension of the solvent was ...
Effects of Natural Osmolytes on the Protein Structure in Supercritical CO2: Molecular Level Evidences
Protein instability in supercritical CO2 limits the application of this green solvent
in enzyme-catalyzed reactions. CO2 molecules act as protein denaturant at high pressure in
supercritical condition. Here, ...
New LHHW kinetic model for CO2 hydrogenation over iron catalyst
A new Langmuir-Hinshelwood-Hougen-Watson type kinetic model for carbon dioxide hydrogenation reaction over a precipitated Fe/Cu/K catalyst is developed in a continuous spinning basket reactor. A number of possible reaction ...
Structural behavior of Candida antarctica lipase B in water and supercritical carbon dioxide: A molecular dynamic simulation study
In this study, molecular dynamic (MD) simulation is used to investigate the effect of
supercritical carbon dioxide on the structural properties of a new variant of Candida antarctica
lipase ...
Kinetic modeling and sensitivity analysis of elongation cycle in protein synthesis
Introduction: One of the famous processes that in many research
studied kinetically in vitro, is the elongation process. Elongation is
meddle step in translation of proteins, during which peptide chain ...
Critical and synergy nodes in insulin-EGF signaling network
Signaling pathways are not isolated from their surroundings. They are also intervened by other signaling
pathways known as “crosstalk mechanism”. One of the most important crosstalk mechanisms is the insulin-
EGF ...
How a protein can remain stable in a solvent with high content of urea: Insights from molecular dynamics simulation of Candida antarcetica lipase B in urea:choline chloride deep eutectic solvent
Deep eutectic solvents (DESs) are utilized as green and inexpensive alternatives to the
classical ionic liquids. It was known that some of DESs can be used as solvent in the
enzymatic reactions to obtain ...