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RISInvestigating the presence of functional RNAi system in Trichomonas vaginalis by targeting a-actinin
Trichomoniasis is the most common non-viral sexually transmitted disease worldwide. This
disease is caused by a flagellated protozoan, Trichomonas vaginalis (TV), that infects human
reproductive tract. ...
Synthetic siRNAs effectively target cystein protease 12 and a-actinin transcripts in Trichomonas vaginalis
The flagellated protozoan Trichomonas vaginalis (T. vaginalis) causes trichomoniasis, a reproductive tract infection, in humans. Trichomoniasis is the most common non-viral sexually transmitted disease worldwide. In addition ...
The inhibitory effect of myostatin-specific siRNA on the differentiation and growth of C2C12 cells
expression of myostatin causes the growth of cells and prevents rapid differentiation. siRNA for silencing mouse myostatin gene was designed by E-RNAi software. This siRNA was designed to be able to inhibit the expression of myostatin gene expression...
Inhibitory effects of siRNA on Myostatin expression in C2C12 cells
expression of myostatin causes the growth of cells and prevents rapid differentiation. siRNA for silencing mouse myostatin gene was designed by E-RNAi software. This siRNA was designed to be able to inhibit the transcription of myostatin. A negative siRNA...
Co-Delivery of Epirubicin and siRNA Using Functionalized Mesoporous Silica Nanoparticles Enhances In vitro and In vivo Drug Efficacy
Development of drug resistance to anticancer drugs is an important challenge for cancer treatment. Recent studies focus on co-delivery of anticancer drugs and siRNA to overcome this challenge. Mesoporous silica nanoparticles (MSNs) are one...
Transcriptomic analysis of dystrophin RNAi knockdown reveals a central role for dystrophin in muscle differentiation and contractile apparatus organization
Background: Duchenne muscular dystrophy (DMD) is a fatal muscle wasting disorder caused by mutations in the dystrophin gene. DMD has a complex and as yet incompletely defined molecular pathophysiology hindering development ...