Search
Now showing items 1-4 of 4
Analysis of novel mutations in BRCA1 in Iranian families with breast cancer
mutations in the BRCA1 and BRCA2 genes. Some recent studies demonstrated that BRCA1 mutations are seen in high-risk women with family histories of BC. In this report we investigated all BRCA1 exons from 40 female patients with family histories of BC and one...
نقش ژنهای BRCA1 و BRCA2 در ابتلاء به سرطان پستان
مقدمه: جهش های ژنی BRCA1 و BRCA2 در سلولهای رده زایا، باعث خطر ابتلاء به سرطان پستان و تخمدان می شوند. ژنهای BRCA1 و BRCA2، عامل 20% از موارد سرطان پستان ارثی هستند. اکثریت جهش های موجود در ژنهای BRCA1 و BRCA2 باعث اتمام زودرس پروتئین می شوند...
Identification of Germline BRCA1 Mutations among Breast Cancer Families in Northeastern Iran
Background: The purpose of this study was to evaluate the prevalence of BRCA1 (MIM: 113705) founder
mutations in familial breast cancer (BC) patients with high risks in Iran. BRCA1 is among the cancer susceptibility genes best known for high...